We’re bringing innovation to the eye care space with integrin-regulating therapy, a new class of drugs for the treatment of ocular diseases.
Risuteganib (Luminate®), our primary investigational compound, is leading the charge with a novel mechanism of action that regulates multiple pathways of oxidative stress response, including mitochondrial dysfunction, which contribute to diseases such as intermediate non-exudative age-related macular degeneration (intermediate dry AMD).
Risuteganib has successfully met the primary endpoint in a Phase 2 clinical trial for intermediate dry AMD and is preparing to commence its Phase 2b/3 clinical program. In addition, risuteganib has successfully met the clinical endpoints in two Phase 2 trials for DME. Data from these studies suggest the ability to treat patients by simultaneously targeting multiple oxidative stress response pathways to restore retinal homeostasis.
Allegro has also expanded the company’s integrin-regulating portfolio with the front-of-the-eye drug candidate ALG-1007. ALG-1007 is a topical therapeutic compound in development for potential use in patients with dry eye disease (DED), a condition affecting millions of people around the world.
As we focus on developing new treatment options for leading causes of blindness, we stay true to our company mission: helping eyecare professionals better serve their patients and improving patients’ quality of life through self-sufficient, functional vision.