David S. Boyer, MD: The role of oxidative stress in DME
http://www.modernretina.com/dme/role-oxidative-stress-dme
Author: Allegro Ophthalmics, LLC
2018
ISOPT Clinical 2018
Randomized, Prospective, Double-Masked, Controlled Phase 2b Trial to Evaluate the Safety and Efficacy of ALG-1001 (Luminate) in DME
Presented by Baruch D. Kuppermann, MD, PhD
March 1, 2018
Tel-Aviv, Israel
Angiogenesis, Exudation, and Degeneration 2018
Integrin Antagonism and Diabetic Macular Edema
Presented by Peter K. Kaiser, MD
February 10, 2018
Miami, FL
Hawaiian Eye & Retina 2018
Prospective, Double-Masked, Placebo-Controlled Phase 2b Trial on the Safety and Efficacy of ALG-1001 (Luminate) in DME
Presented by Peter K. Kaiser, MD
January 17, 2018
Maui, Hawaii
VIDEO: Research targets different pathways for treating DME
WAILEA, Hawaii — At Retina 2018, Peter K. Kaiser, MD, discusses research targeting different pathways for treating diabetic macular edema.
To view the video, please visit Healio.com/OSN: “Research targets different pathways for treating DME”
VIDEO: Anti-integrin trials in line with scientific expectations
WAILEA, Hawaii — At Retina 2018, Pravin U. Dugel, MD, discusses the ongoing clinical trials for Allegro’s anti-integrin therapy in the treatment of retinal disease.
To view the video, please visit Healio.com/OSN: “Anti-integrin trials in line with scientific expectations”
The Latest Data on Anti-Integrin Therapy for Patients with DME
In a phase 2b study, ALG-1001 showed additional efficacy in patients who had plateaued on chronic anti-VEGF therapy.
To read the full article please visit Retina Today: “The Latest Data on Anti-Integrin Therapy for Patients with DME”
VIDEO: Luminate after Avastin shows early promise for treating diabetic macular edema
NEW ORLEANS ― At the American Academy of Ophthalmology meeting here, Baruch D. Kuppermann, MD, PhD, director of the Gavin Herbert Eye Institute at UC Irvine, discusses results from the DEL MAR trial of Luminate (Allegro) for the treatment of diabetic macular edema.
To view the video, please visit Healio.com/OSN: “Luminate after Avastin shows early promise for treating diabetic macular edema”
VIDEO: Novel anti-integrin therapy
Baruch D. Kuppermann, MD, PhD, discusses Novel anti-integrin therapy at the Ophthalmology Innovation Summit @AAO 2017.
To view the video, please visit EyeWorld Video Reporter: “Novel anti-integrin therapy”
VIDEO: Allegro at the Ophthalmology Innovation Summit @AAO 2017
Vicken Karageozian, MD, discusses results of a phase-2 trial of an anti-integrin drug for diabetic macular edema.
To view the video, please visit EyeWorld Video Reporter: “Allegro at the Ophthalmology Innovation Summit @AAO 2017”
Novel DME treatment derives from multimodal activity
Anti-integrin therapy addresses pathophysiology; targets early point in pathogenic pathway.
To read the full article please visit Ophthalmology Times: “Novel DME treatment derives from multimodal activity”
“ALG:1001: Turning Off the Machinery of Angiogenesis”
ALG-1001 (Luminate®, Allegro Ophthalmics), a first-in-class integrin peptide therapy, met the primary endpoint of vision non-inferiority to bevacizumab (Avastin, Genentech Inc.), an anti-vascular endothelial growth factor therapy (anti-VEGF), with 12-week durability in a population of patients with mostly chronic diabetic macular edema (DME).
ALG-1001 seems to be a strong player with different mechanisms of action that benefit patients who have been receiving chronic anti-VEGF therapy and those who are treatment naïve.
To read the article, please visit Ophthalmology Times: “ALG-1001: Turning off the machinery of angiogenesis”