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DME retina imagery

Meeting Unmet Needs

Allegro has progressed its R&D program for its lead drug candidate, Luminate®, as a novel treatment option for DME

Luminate® has been studied in two U.S. phase 2b trials involving 218 DME patients, demonstrating safety and efficacy across doses of up to 3 mg. It achieved equivalent vision gains to the current standard of care1 – anti-VEGF treatment – with fewer total injections.2

Additionally, Luminate® has been shown to be an effective treatment option for DME patients who either do not respond or have an inadequate response to anti-VEGF therapy.2

Unlike anti-VEGF or corticosteroid therapies for DME, Luminate®2:

  • Has demonstrated antiangiogenic, anti-inflammatory, and neuroprotective activities
  • Deactivates the machinery of angiogenesis
  • Stabilizes the retina to return it to a condition of homeostasis—a normal balance

Read more about Luminate® in the news.

  

Reference: 1. Singer MA, Kermany DS, Waters J, et al. F1000Res. 2016;5. 2. Data on file.